Tuesday, August 5, 2014

5 Signs and Symptoms of Advanced Multiple Myeloma

Multiple myeloma is a kind of cancer that's triggered by malignant plasma cells in your body. The malignant plasma cells form growths, mainly within the bone marrow. When large amounts of those malignant growths grow in multiple locations in your body, the problem is known as multiple myeloma. Based on the Worldwide Myeloma Foundation, multiple myeloma doesn't frequently produce any signs and symptoms inside a patient before the individual is incorporated in the advanced multiple myeloma stages.

Whats are those Five signs?

Bone Discomfort

Multiple myeloma generally attacks the bone marrow in your body, the key signs and signs and symptoms of advanced multiple myeloma is bone discomfort and bone weakness. Back discomfort or discomfort within the ribs, legs and arms is a very common symbol of the problem and it is frequently more serious during the night or after long periods of lack of exercise. Actually, based on the U.S. Dept of Health insurance and Human Services Agency for Healthcare Policy and Research, patients older than fifty years old that have acute back discomfort in excess of 30 days ought to be evaluated for the existence of multiple myeloma when they also experience a number of another signs and symptoms the condition presents.

Central Nervous System Complications

Advanced multiple myeloma can attack the nervous system and cause numbness and weakness of braches. Abnormal proteins which are created through the malignant myeloma cells make calcium levels in your body to increase, which could slow bloodstream circulation. If this happens, central nervous system complications for example lightheadedness, confusion and stroke-like signs and symptoms can happen within the patient.

Blood circulation System Complications

Advanced multiple myeloma suppresses the development of ordinary marrow cells, which in turn causes an insufficiency of both red-colored and whitened bloodstream cells in addition to bloodstream platelets. Red-colored bloodstream cell deficiency, or anemia, leads to difficulty breathing, fatigue and general weakness. Whitened bloodstream cell deficiency reduces our body’s potential to deal with infections, leading to an elevated chance of severe ailments like pneumonia. A minimal bloodstream platelet count can prevent bloodstream-clots from occurring, so even small cuts and scrapes pose a danger for serious bleeding.

Kidney Signs and symptoms

Excessive levels of myeloma protein will lessen the kidney’s capability to correctly process waste materials, fluid and salt. Light chain proteins known as Bence Johnson proteins, start to come in the urine and may cause kidney lesions to happen within the kidney and produce about severe kidney damage.


People struggling with advanced multiple myeloma are in a greater risk for developing infections in their body. Including minor infections, for example infection to some cut or scrape, or even more severe infections for example pneumonia or meningitis.

What is Bone Marrow Biopsy?

A bone marrow biopsy is removing soft tissue, known as marrow, from the inside bone. Bone marrow can be found in the hollow a part of most bones. It will help form bloodstream cells.

The way the Test Is Carried out

A bone marrow biopsy might be completed in the healthcare homes or perhaps in a healthcare facility. The sample might be obtained from the pelvic or breast bone. Sometimes, other locations are utilized.

The healthcare provider will clean your skin and inject a mind-numbing medicine in to the area. Rarely, you might be given medicine that will help you relax.

The physician card inserts the biopsy needle in to the bone. The middle of the needle is taken away and also the hollowed needle is moved much deeper in to the bone. This captures a small sample, or core, of bone marrow inside the needle. The sample and needle are removed. Pressure along with a bandage are put on the biopsy site.

A bone marrow aspirate can also be carried out, usually prior to the biopsy is taken. Following the skin is numbed, the needle is placed in to the bone, along with a syringe can be used to withdraw the liquid bone marrow. If this sounds like done, the needle is going to be removed and only repositioned, or any other needle might be employed for the biopsy.

How you can Get ready for the bone marrow biopsy

Tell the healthcare provider:

    If you're allergic to the medicines

    What medicines you're taking

    For those who have bleeding problems

    If you're pregnant

You have to sign a consent form.

The way the bone marrow biopsy Will Feel

You'll feel a clear, crisp sting once the mind-numbing prescription medication is injected. You might feel a short, sharp discomfort once the liquid (aspirate) is taken away.

The biopsy needle might also result in a brief, usually more dull, discomfort. Since within the bone can't be numbed, this test could cause some discomfort. However, not every patients have such discomfort.

Why the exam Is Carried out

Your physician may order this test for those who have abnormal types or amounts of red-colored or whitened bloodstream cells or platelets on the complete bloodstream count (CBC).

This test can be used to identify leukemia, infections, some kinds of anemia, along with other bloodstream disorders. It could also be accustomed to help determine whether a cancer has spread or taken care of immediately treatment.

Normal Results

An ordinary result means the bone marrow consists of the correct number and kinds of bloodstream-developing (hematopoietic) cells, body fat cells, and connective tissue.

What Abnormal Results Mean

Abnormal results might be because of cancer from the bone marrow (leukemia or Hodgkin's disease).

The outcomes may identify the reason for anemia (too couple of red-colored bloodstream cells), abnormal whitened bloodstream cells, or thrombocytopenia (too couple of platelets).

Additional conditions to which the exam might be carried out:

    Disseminated coccidioidomycosis (an appearance-wide yeast infection)

    Hairy cell leukemia

    Hodgkin's lymphoma

    Idiopathic aplastic anemia

    Multiple myeloma

    Myelodysplastic syndrome (MDS)


    Non-Hodgkin's lymphoma

    Polycythemia vera

    Primary amyloid

    Primary myelofibrosis

    Primary thrombocythemia

    Secondary aplastic anemia

    Secondary systemic amyloid

    Waldenstrom's macroglobulinemia


There might be some bleeding in the puncture site. More severe risks, for example serious bleeding or infection, are extremely rare.


This test is frequently carried out when you will find issues with the various bloodstream cells. The individual might be at elevated risk for bleeding, infection, or any other problems.

Tuesday, June 5, 2012

Myeloma Prognosis

If you are wondering what a myeloma prognosis is, it is simply a medical opinion by an expert that will outline the treatment and outcome of the disease. A prognosis is arrived at after carefully analyzing the symptoms of the disease, then conducting a biopsy to check whether there are any myeloma cells present. If there is a presence then appropriate tests are conducted keeping a variety of factors in mind.

Tests such as blood tests, urine tests, MRIs and CT Scans are usually a part of myeloma prognosis. After the test results are brought back to the doctor’s clinic. The doctor will study them thoroughly and check for three or four key things. He will check for the stage of the cancer. There are typically four stages. Smoldering stage or the early stage is when there are a number of myeloma cells present in the body, but there is no apparent bone damage. The stages that develop are Stage 1, 2 and 3.

Once the stage is arrived at, the doctor will check for the location of the cancer and how far and wide it has spread. He will also check whether any vital organs have been damaged like the kidney. The myeloma prognosis will be arrived at keeping all these things into consideration and also a number of research findings and statistics.

What patients should know is that myeloma prognosis is only a medical prediction and the outcome may vary. There is no treatment that cures myeloma, however, the growth of cells can be curbed to a great extent. There are a number of treatments too that are a part of the medical myeloma prognosis. The treatments for myeloma cancer may vary again, depending on the factors that have been discussed above.
A few treatments that are usually prescribed are watchful waiting, stem cell transplant, induction therapy and radiation therapy. The prognosis may suggest either one or a combination of the treatments discussed. The prognosis will also outline that the treatments will have a number of side effects.

Myeloma prognosis has to be conducted with absolute care. When developing a plan of action for the treatment, it is important that the oncologists consider all the factors and prescribes all the tests that are necessary for successful detection. Over and above the factors that have been mentioned above, the oncologist will also have to keep in mind the lifestyle of the patient as well as the diet.

Myeloma prognosis in the early stage of the cancer may advice patients to wait and delay the treatment for cancer. This is advised because no apparent symptoms are present. When patients wait they have the advantage of not experiencing the stressful side effects of cancer treatment. However, it is very important and crucial that patients check in with their doctors on a regular basis to ensure that the cells do not spread.

In most cases, smoldering myeloma does culminate into multiple myeloma, and this is when the treatments have to be taken. A proper myeloma prognosis is extremely important to take on treatment that can deliver positive results.

Wednesday, May 23, 2012

Chemotherapy, Stem Cell Transplant : Possible Methods For Myeloma Treatment

Multiple myeloma, it is a type of blood cancer of the plasma cells in the bone marrow. This is a very rare type of cancer, which affects the blood cells and bones. The disease becomes incurable in advance stage where there is treatment available to deal with this disease. People can go for myeloma treatment through the conventional way or they can choose to take alternate treatment like homeopathy or Ayurvedic. The main target of all these method of for myeloma treatment is to give relief and aim to cure the patient who is suffering from this disease. However, all the method differs from each other.

Different Ways To Treat Myeloma
In conventional method of myeloma treatment, there are several types of drugs, which are used for the treatment. They are taken either alone or in combination as suggested by the doctors. All the types of treatment through conventional treatment have been divided into several groups they are Initial or induction chemotherapy, maintenance therapy, consolidation therapy and salvage therapy.

Each drug targets to kill cancer cells though in different ways. Chemotherapy is known to kill the fast growing myeloma cancer cells while it also harms normal cells and it has its share of side effects. Targeted therapy is used to block the unnatural growth of myeloma cancer cells, it also block the action of the M-protein in the body which induce the growth of cancer cells.

Steroids are also used to treat myeloma cancer, as it is believed that steroid is helpful to kill the cancer cells. It can be used alone or in combination with other drugs to treat myeloma cancer. The drugs are to be taken orally or through a vein.

Stem cell transplant
Stem cell transplant is modern way of myeloma treatment. This is the most advance form of treatment, which is better than the other conventional treatment available; however, this is a costly affair. This treatment will need the patient to take high dose of drugs, which would destroy both your normal blood cells as well as the cancer cells. After that, the patient would receive through his vein the healthy stems cells like the case of blood transfusion.

This new stem cells helps to develop new health blood cells and replace the dead ones, which were destroyed by the high dose of drugs. Mainly done in hospitals, a patient may have to take two or more stem cell transplants. These stem cells may come from your own body or somebody else may donate the same as per requirement.

Different Types and Method of Stem Cell Transplant
The process, which would require your cells, is known as autologous stem cell transplant and an allogeneic stem cell transplant is the one, which uses the healthy stem cells of donors. A synergistic stem cell transplant is the one that uses stem cells of an identical healthy twin of the patient. For myeloma treatment stem cell transplant can be done through two ways -- one is peripheral blood stem cell transplant and the other is bone marrow transplant.

Wednesday, May 16, 2012

Multiple Myeloma – Causes, Symptoms, Treatment

There are many blood cells in our body and they are most essential for performing the functions of our body properly. Multiple Myeloma is a growth of cancerous plasma cells or malfunctioning of these blood cells. When these normal cells transform into abnormal cells and these abnormal cells increase and accumulate unmanageably, then the body is affected by cancer. In the affected area of the body the abnormal cells accumulate to form tumors or bodily masses which have the power to cause damage to the adjacent organs or tissues and infect them through the lymphatic system and the blood vessels which run into the other organs located farther.

Multiple Myeloma Causes
The reason of Multiple Myeloma is unknown but few causes are supposed to causer this disease. One may be affected by this disease due to some inherited abnormalities, as an influence of high doses of radiation, due to malfunctioning of the internal body system, some viral infection, vulnerability to certain harmful chemicals and the environmental conditions in the work places of book binders, shipyard workers, petrochemical industry workers, cosmetologists, leather workers, metallurgic industry workers etc.

multiple myeloma cancer
multiple myeloma

Multiple Myeloma Symptoms
The symptoms of Multiple Myeloma depend on the increasing plasma cells and the symptoms are nonspecific.
• Sudden osteoporosis at a young age may be a sign of Multiple Myeloma. Abnormality in height or unlikely changes in the spinal curvature is a sign of myeloma in the vertebral bones.
• The ribs and the spinal cord are the area commonly affected by myeloma. Therefore symptoms also include back pain, pain in the walls of the chest, a burning sensation, tingling, and loss of functioning of the limbs or joints.
• Incessant bleeding from the nose, mouth, or any other internal part of the body, problems in vision, breathing related problems, pain in the chest and other neurological problems like mental confusion, headache, stroke, sleeplessness, lethargic feelings etc. are the sign of hyper viscosity.
• Low count of the white blood cells is also one of the common symptoms of the disease.
• Another familiar symptom of myeloma is anemia which includes paleness, breathing problems and extreme fatigue.
• Low platelet counts, amyloidosis and cryoglobulinemia are also some of the usual symptoms of myeloma.
Initially the symptoms do not show up and remain dormant. But as the disease grows internally the symptoms get revealed more and more.

Multiple Myeloma Treatment
Initially, most of the doctors recommend blood tests and urine tests along with a fixed routine of physical checkup for the treatment of Multiple Myeloma. Frequent chest x-rays need to be done to recognize the activities within the bones. It is always advisable to take expert advice from a blood cancer specialist, than go to a general physician. Sometimes the doctors would recommend that you visit an oncologist or a hematologist for better treatment of the disease.

However, we all know that there is no other better way than the prevention of the disease. So avoiding the risk factors and maintaining a healthy lifestyle is better than running for treatment.